Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance The Journal of Pharmacology and Experimental Therapeutics Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Rigid flexible nanocarriers loaded with active peptides for antioxidant and anti inflammatory applications in skin ScienceDirect Intermediate Cu(II) Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction Inorganic Chemistry