Frontiers Glutathione responsive and exhausting metal nanomedicines for robust synergistic cancer therapy Catabolism of extracellular glutathione supplies cysteine to support tumours Nature A study shows that the antioxidant glutathione feeds cancer cells An integrative multi omics analysis leveraging Mendelian randomization and subsequent experimental validation prioritizes glutathione S transferase mu 5 (GSTM5) as a genomic stability related gene and a therapeutic vulnerability to PLK1 inhibition in