Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Before you spend money on glutathione, read this first. Topical, oral, injectable what actually works and what's just marketing? #funskincare #funingredientsinfographic101 Tylenol And Glutathione Invigor Medical Model Could Help Counteract Poisoning from Popular Painkiller Duke Today