Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Lingual melanotic macule the first case report in an adult patient* Anais Brasileiros de Dermatologia Oral Melanotic Macule: Symptoms and Treatment Skinsight Brown macules & small patches (<2 cm) Not all brown spots are the same! Freckles, lentigo, moles, or melanoma each tells a different story. Even color and smooth surface