Nicotine free e cigarettes can damage blood vessels Penn Medicine Don't be foolede cigs or vapes may be less harmful than cigarettes, but less harmful doesn't mean safe. Vapes can contain harmful substances including nicotine, heavy metals like lead, volatile organic compounds and Side Effects of Vaping Without Nicotine: Flavors, Cannabis, CBD An e cigarette is a battery operated device that heats liquid nicotine, flavoring, and other additives to create an aerosol. This JAMA Patient Page describes e cigarettes and the potential health effects of vaping. https: ja.ma 4dbZqrL