Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance The Journal of Pharmacology and Experimental Therapeutics TOLERANCE & TACHYPHYLAXIS Tolerance and Tachyphylaxis Drug Tolerance Drug Tachyphylaxis Pharmacology Made Easy Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a